Vineyards expand from 42° 35' geographic latitude on north to 42° 13' geographic latitude on south. For the most part it's situated on altitudes from 390 m to 780 m. Area where vineyards are grown is on altitudes from 420 m to 650 m.

Altitude of the region gradually decreases going from edge toward central part of the region (medium-steep to gentle slopes of the terrain where vineyards are located), and it's characterized by the following types of soil: vertisol and rancer, sirozem, litosol on granite, granodiorit and kvarclatit. Less common are fluvisol, euteric cambisol, and other types of soil.

Vineyards are mostly located on south, south east, and east expositions. Topographic - relief characteristics of this area are mountain Rujan on south (696 m), as well as slopes of mountains ending near the river Juzna Morava on south and south east.

There are two prominent parts: Morava near Vranje  and valley of Vranje and Bujanovac.

Valley of Vranje and Morava consists out of two parts, outer basin hills and valley part of the river Juzna Morava with its tributaries.

Valley of Vranje and Bujanovac is lowland basin terrain. The area is dominated by misty and flood forests of red oak, ash,  alder, poplar, and other.

On the north side of the region there is canon Grdelica, which represents the most prominent mountain feature of the basin of the river Juzna Morava; in the area most common are forests of Turkey oak, common oak, and other, while in the south east part of the region one can see forest belt of mountain trees like beech. Also, there are small orchards and small plots with arable crops,.

Vranje region includes the following vineyards:

1.9.1. Surdulica vineyards - Surdulica;

1.9.2. Vrtogos vineyards - Vrtogos;

1.9.3. Bustranje vineyards - Bustranje.