Fruska Gora was declared a national park in 1960. The main feature of the national park is the existence of many endangered, and rare species of plants and animals.Pastures and fertile fields, vineyards and orchards decorate the slopes and lower parts of Fruska Gora, while areas at altitudes above 300 meters are covered by dense, deciduous forests of oak, hornbeam, beech, linden, and other trees.

There are 1,500 plant species found on Fruska Gora, from which only 1.000 species are inside of boundaries of the national park. Many of them are relicts and endemits, and over 50 species are listed as natural rarities of Serbia. Rare plants are laurel jeremicak, chaf, steppe cherry, Adonis vernalis, low iris, and 20 species of the orchid family. There are about 200 species of birds on Fruska Gora (burrowing eagle, woodpecker, gray tit, and many others), and it is the only habitat in Serbia where a cruiser eagle nestles. Of mammals one can see rare species such as wild cat, badger, marten and many species of bats.

A part of the national park meats river Danube. Fruska Gora is famous for its many monasteries. Monasteries on Fruska Gora make a unique group of densely arranged monasteries, created in the time period from the fifteenth to the eighteenth century, with the majority being build on the remains of earlier temples. Throughout history there were more than thirty monasteries, and today there are sixteen, of which some are in ruins or only partially restored.